Table 3.
Diagnostic Characteristics of Administrative Data-Defined AKI (Admin-AKI) in Post-Cardiac Surgery Patients.
| Detecting any Chart-AKI Total n = 355 for AKISCr and for AKISCrUO; n = 204 for AKIUO | |||
|---|---|---|---|
| Diagnostic characteristica | SCr criteria 170 AKI events |
UO criteria 51 AKI events |
SCr or UO criteria 185 AKI events |
| Sensitivity | 5.9% (4.6-7.6) | 13.7% (10.1-18.5) | 5.9% (4.7-7.6) |
| Specificity | 99.5% (98.6-99.8) | 98.5% (97.5-99.2) | 100% (99.2-100) |
| PPV | 90.9% (77.3-97.4) | 70.0% (54.2-82.4) | 100% (88.2-100) |
| NPV | 53.5% (51.5-55.4) | 82.0% (80.0-83.8) | 49.4% (47.5-51.4) |
| Detecting Chart-AKI stage 2 or worse | |||
| SCr criteria 64 AKI events |
UO criteria 11 AKI events |
SCr or UO criteria 64 AKI events |
|
| Sensitivity | 14.1% (10.8-18.2) | 18.2% (8.7-32.6) | 14.1% (10.8-18.2) |
| Specificity | 99.3% (98.7-99.7) | 96.7% (95.6-97.6) | 99.3% (98.7-99.7) |
| PPV | 81.8% (67.4-91.2) | 20.0% (9.6-35.5) | 81.8% (67.4-91.2) |
| NPV | 84.0% (82.5-85.4) | 96.3% (95.2-97.2) | 84.0% (82.5-85.4) |
| Detecting Chart-AKI stage 3 | |||
| SCr criteria 32 AKI events |
UO criteria 7 AKI events |
SCr or UO criteria 35 AKI events |
|
| Sensitivity | 15.6% (10.6-22.3) | 14.3% (4.0-34.1) | 14.3% (9.7-20.5) |
| Specificity | 98.1% (97.4-98.7) | 96.4% (95.2-97.2) | 98.1% (97.3-98.7) |
| PPV | 45.5% (31.7-59.8) | 100% (2.8-24.7) | 45.5% (31.7-59.8) |
| NPV | 92.2% (90.9-93.2) | 97.6% (96.5-98.3) | 91.3% (90.0-92.4) |
Note. Chart-AKI = AKI defined by medical chart review (reference standard); AKISCr = acute kidney injury defined using serum creatinine criteria; AKIUO = acute kidney injury defined using urine output criteria; AKISCrUO = acute kidney injury defined using serum creatinine and urine output criteria; SCr = serum creatinine; UO = urine output; PPV = positive predictive value; NPV = negative predictive value.
a
Estimates of sensitivity, specificity, PPV, and NPV are presented with 95% confidence intervals.