Table 3.

Linear regression associations between migraine frequency (migraine days per month) and family history of migraine.

	β	95% CI	p-value
Model 1
Family history of migraine			0.14
(0 vs. 1 affected parent,	−0.16	−0.57; 0.26	0.46
0 vs. 2 affected parents)	0.69	−0.20; 1.58	0.13
Age (years)	0.03	0.01; 0.05	0.001
Sex (male vs. female)	0.07	−0.51; 0.65	0.81
Lifetime depression	0.57	0.17; 0.97	0.005
Acute medication use	0.31	0.28; 0.34	<0.001
Migraine subtype (MA vs. MO)	1.05	0.64; 1.45	<0.001
Age-at-onset of migraine (years)	−0.03	−0.05; 0.01	0.01
Model 2
Family history of migraine			0.09
(0 vs. 1 affected parent,	1.08	−0.05; 2.21	0.06
0 vs. 2 affected parents)	2.20	−0.02; 4.42	0.05
Age (years)	0.03	0.01; 0.05	0.001
Sex (male vs. female)	1.02	0.06; 1.99	0.04
Lifetime depression	0.56	0.16; 0.95	0.006
Acute medication use	0.31	0.28; 0.34	<0.001
Migraine subtype (MA vs. MO)	1.04	0.64; 1.45	<0.001
Age-at-onset of migraine (years)	−0.03	−0.05; −0.01	0.009
Family history * sex			0.05
(0 vs. 1 affected parent, male vs. female,	−1.43	−2.64; −0.21	0.02
0 vs. 2 affected parents, male vs. female)	−1.77	−4.19; 0.64	0.15

Note: Data are unstandardized regression coefficients (β) with 95% confidence intervals (CI) and p-values. Model 1 was adjusted for age, sex, lifetime depression diagnosis, acute medication use, migraine subtype (MO: migraine without aura; MA: migraine with aura), and age-at-onset of migraine. Model 2 was additively adjusted for the interaction term of family history of migraine and sex.