Table 4.
Factors associated with time to any discontinuation of HIV preexposure prophylaxis (n = 602)
| Covariate | No Disc (N = 376) | 1 Disc (N = 178) | 2 Disc (N = 40) | 3 Disc (N = 6) | 4 Disc (n = 2) | Any disc | |
|---|---|---|---|---|---|---|---|
| HR (95% CI) | aHR (95% CI) | ||||||
| Age (n, %) | |||||||
| 18 to 24 | 37 (9.8) | 28 (15.7) | 10 (25.0) | 2 (33.3) | – | 2.2 (1.5, 3.2) | 2.0 (1.4, 2.9) |
| 25 to 29 | 69 (18.4) | 58 (32.6) | 19 (47.5) | 2 (33.3) | 1 (50.0) | 2.2 (1.6, 3.1) | 2.2 (1.6, 3.1) |
| 30 to 39 | 130 (34.6) | 51 (28.7) | 5 (12.5) | 1 (16.7) | 1 (50.0) | Ref | Ref |
| 40+ | 140 (37.2) | 41 (23.0) | 6 (15.0) | 1 (16.7) | – | 0.8 (0.5, 1.1) | 0.8 (0.5, 1.2) |
| Gender (n, %) | |||||||
| Cisgender male | 367 (97.6) | 166 (93.3) | 36 (90.0) | 6 (100.0) | 2 (100.0) | Ref | Ref |
| Cisgender female | 2 (0.5) | – | – | – | – | — | — |
| Transgender female | 5 (1.3) | 11 (6.2) | 3 (7.5) | – | – | 3.0 (1.7, 5.1) | 2.0 (1.2, 3.4) |
| Transgender male | 2 (0.5) | 1 (0.6) | 1 (2.5) | – | – | 1.5 (0.5, 5.1) | 0.9 (0.3, 2.5) |
| Race and ethnicity (n, %) | |||||||
| Non‐Hispanic White | 289 (76.9) | 128 (71.9) | 27 (67.5) | 4 (66.7) | 2 (100.0) | Ref | Ref |
| Black | 20 (5.3) | 13 (7.3) | 4 (10.0) | 1 (16.7) | – | 1.5 (0.9, 2.3) | 1.4 (0.9, 2.0) |
| Asian or Pacific Islander | 10 (2.7) | 7 (3.9) | 2 (5.0) | – | – | 1.8 (0.9, 3.4) | 1.4 (0.7, 2.9) |
| Multiracial/other | 35 (9.3) | 18 (10.1) | 2 (5.0) | 1 (16.7) | – | 1.0 (0.7, 1.6) | 0.9 (0.6, 1.4) |
| Hispanic or Latinx | 22 (5.9) | 12 (6.7) | 5 (12.5) | – | – | 1.5 (0.9, 2.5) | 1.2 (0.7, 2.2) |
| Relationship status (n, %) | |||||||
| Single | 214 (56.9) | 114 (64.0) | 28 (70.0) | 4 (66.7) | 2 (100.0) | Ref | Ref |
| HIV‐infected primary partner | 53 (14.1) | 27 (15.2) | 7 (17.5) | 2 (33.3) | – | 0.9 (0.6, 1.3) | 1.0 (0.8, 1.4) |
| HIV‐uninfected primary partner | 109 (29.0) | 37 (20.8) | 5 (12.5) | – | – | 0.6 (0.4, 0.8) | 0.8 (0.6, 1.1) |
| No. of mental health disorders (mean, SD) | 0.9 (1.0) | 1.1 (1.1) | 1.4 (1.2) | 2.0 (1.1) | 3.5 (0.7) | 1.3 (1.2, 1.5) | 1.2 (1.1, 1.4) |
| Substance use disorder (n, %) | |||||||
| Alcohol | 37 (9.8) | 20 (11.2) | 8 (20.0) | 2 (33.3) | 2 (100.0) | 1.7 (1.2, 2.4) | 1.3 (0.9, 1.9) |
| Non‐alcohol, recreational druga | 29 (7.7) | 24 (13.5) | 9 (22.5) | 2 (33.3) | 1 (50.0) | 1.9 (1.3, 2.6) | 1.2 (0.8, 1.7) |
| Insurance status (n, %) | |||||||
| Private (any) | 336 (89.4) | 144 (80.9) | 33 (82.5) | 5 (83.3) | – | Ref | Ref |
| Public (Medicaid or Medicare) | 40 (10.6) | 34 (19.1) | 7 (17.5) | 1 (16.7) | 2 (100.0) | 1.9 (1.4, 2.6) | 1.3 (1.0, 1.9) |
Bold font indicates hazard ratios for which 95% confidence intervals do not include the value of 1. aHR, adjusted hazard ratio; CI, confidence intervals; ref, referent; Disc, discontinuation; HR, hazard ratio; SD, standard deviation. aIncludes drug use disorders related to cocaine, crack, crystal, GHB, heroin, poppers, ketamine, MDMA, opioids, LSD and benzodiazepine.