Table 2.
Characteristics of patients with clinical cure and clinical failure
| Clinical cure (n = 229) | Clinical failure (n = 20) | P value | |
|---|---|---|---|
| Age (years) | 60 (45–73) | 56 (46–71) | 0.412 |
| Male sex | 94 (41) | 7 (35) | 0.597 |
| Urologic history | |||
| Indwelling urinary catheter | 7 (3) | 0 | 0.428 |
| Urinary tract disordera | 71 (31) | 4 (20) | 0.304 |
| Recurrent UTIb | 50 (22) | 7 (35) | 0.191 |
| Comorbidity | |||
| Diabetes mellitus | 32 (14) | 1 (5) | 0.256 |
| Malignancy | 16 (7) | 1 (5) | 0.735 |
| Heart failure | 21 (9) | 0 | 0.157 |
| Cerebrovascular disease | 12 (5) | 1 (5) | 0.963 |
| Chronic renal insufficiency | 8 (3) | 1 (5) | 0.729 |
| COPD | 27 (11) | 2 (10) | 0.899 |
| Immunocompromised | 14 (6) | 1 (5) | 0.841 |
| Presentation | |||
| At emergency department | 160 (70) | 15 (75) | 0.630 |
| Antibiotic pre-treatment | 71 (31) | 2 (10) | 0.048 |
| Fever duration, hours | 36 (18–72) | 48 (24–120) | 0.279 |
| Dysuria | 175/224 (78) | 13/19 (68) | 0.332 |
| Flank pain | 142/225 (63) | 17 (85) | 0.049 |
| Suprapubic pain | 116/222 (52) | 11 (55) | 0.814 |
| Perineal pain | 11/222 (5) | 0/19 (0) | 0.321 |
| Systolic BP, mmHg | 130 (116–146) | 130 (115–150) | 0.753 |
| Diastolic BP, mmHg | 74 (63–85) | 72 (68–83) | 0.585 |
| Heart rate, beats/minute | 93 (80–107) | 96 (78–110) | 0.695 |
| Cultures | |||
| Positive urine culture | 158 (69) | 13 (65) | 0.712 |
| Escherichia coli | 133/158 (84) | 10/13 (77) | 0.497 |
| Positive blood culture | 42/220 (19) | 3 (15) | 0.654 |
| Positive urine and/or blood culture | 169 (74) | 14 (70) | 0.712 |
| Treatment | |||
| Short antimicrobial treatment (7 days) | 82 (36) | 10 (50) | 0.207 |
| Days of AB, mean (SD) | 11 (3.3) | 11 (3.5) | 0.252 |
| Ciprofloxacin | 208 (91) | 18 (90) | 0.902 |
| Amoxicillin (± clavulanic acid) | 11 (5) | 2 (10) | 0.316 |
| TMP/SMX | 5 (2) | 0 | 0.504 |
| Otherc | 5 (2) | 0 | 0.504 |
| Initial intravenous dose(s) of AB | 135 (59) | 12 (60) | 0.927 |
| Randomized | 155 (68) | 10 (50) | 0.109 |
| Outpatient treatment | 89 (39) | 7 (35) | 0.733 |
Data presented as number (%) or median (IQR)
BP blood pressure, AB antibiotics, TMP/SMX trimethoprim-sulfamethoxazole
aany functional or anatomical abnormality of urinary tract except urinary catheter
b≥3 UTIs in past 12 months or ≥ 2 UTIs in past 6 months
ccefuroxime iv n = 2, meropenem iv n = 1, moxifloxacin n = 1, flucloxacillin n = 1