Table 4.
Top 15 diseases with the highest degree in bipartite graphs generated from the HPO-Orphanet, EMR, and HPO-Orphanet+
| HPO-Orphanet Graph | EMR Graph | HPO-Orphanet+ Graph |
|---|---|---|
| 22q11.2 deletion syndrome | multiple myeloma | multiple myeloma |
| melas | hodgkin lymphoma | hodgkin lymphoma |
| granulomatosis with polyangiitis | follicular lymphoma | giant cell arteritis |
| marfan syndrome | giant cell arteritis | follicular lymphoma |
| neurofibromatosis type 1 | primary sclerosing cholangitis | primary sclerosing cholangitis |
| trisomy 18 | myasthenia gravis | 22q11.2 deletion syndrome |
| eosinophilic granulomatosis with polyangiitis | granulomatosis with polyangiitis | granulomatosis with polyangiitis |
| giant cell arteritis | pulmonary arterial hypertension | melas |
| acromegaly | liposarcoma | myasthenia gravis |
| primary sclerosing cholangitis | eosinophilic esophagitis | rheumatic fever |
| systemic sclerosis | rheumatic fever | marfan syndrome |
| dermatomyositis | klatskin tumor | dermatomyositis |
| osteogenesis imperfecta | tetralogy of fallot | pulmonary arterial hypertension |
| addison disease | cystic fibrosis | craniopharyngioma |
| cushing syndrome | craniopharyngioma | neurofibromatosis type1 |