Table 3.
Results of the sensory evaluation questionnaire about edoxaban OD tablets shown by the group
| Group 1 (30 mg without water)c N = 32 | Group 3 (30 mg with water)d N = 32 | Group 2 (60 mg without water)e N = 21 | Group 4 (60 mg with water)f N = 21 | ||
|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | ||
| Question 1: Difficulty in ingestion (current) | Yes | 6 (18.8) | 5 (15.6) | 2 (9.5) | 1 (4.8) |
| No | 26 (81.3) | 27 (84.4) | 19 (90.5) | 20 (95.2) | |
| Question 2: Difficulty in identifying (current) | Yes | 2 (6.3) | 3 (9.4) | 0 (0.0) | 2 (9.5) |
| No | 30 (93.8) | 29 (90.6) | 21 (100.0) | 19 (90.5) | |
| Question 3: Number of drugs taken simultaneously | 1 typea | 3 (9.4) | 3 (9.4) | 1 (4.8) | 3 (14.3) |
| 2 types | 6 (18.8) | 2 (6.3) | 4 (19.1) | 1 (4.8) | |
| ≥3 types | 23 (71.9) | 27 (84.4) | 16 (76.2) | 17 (81.0) | |
| Question 4: Degree of satisfaction | Unsatisfactory | 5 (15.6) | 1 (3.1) | 7 (33.3) | 0 (0.0) |
| No difference | 15 (46.9) | 21 (65.6) | 6 (28.6) | 14 (66.7) | |
| Satisfactory | 12 (37.5) | 10 (31.3) | 8 (38.1) | 7 (33.3) | |
| Question 5: Ease in identifying | Quite easy | 7 (21.9) | 7 (21.9) | 6 (30.0) | 8 (38.1) |
| Easierb | 8 (25.0) | 11 (34.4) | 7 (35.0) | 3 (14.3) | |
| More difficultb | 5 (15.6) | 3 (9.4) | 4 (20.0) | 4 (19.1) | |
| Quite difficult | 12 (37.5) | 11 (34.4) | 3 (15.0) | 6 (28.6) | |
| Question 6: Size | Very large | 1 (3.6) | 0 (0.0) | 0 (0.0) | 1 (5.0) |
| Slightly large | 10 (35.7) | 19 (61.3) | 16 (84.2) | 13 (65.0) | |
| Slightly small | 16 (57.1) | 12 (38.7) | 3 (15.8) | 6 (30.0) | |
| Very small | 1 (3.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Question 7: Taste at the time of disintegration | Very good | 5 (16.7) | 5 (20.0) | 1 (5.3) | 5 (27.8) |
| Relatively good | 16 (53.3) | 19 (76.0) | 12 (63.2) | 12 (66.7) | |
| Relatively bad | 9 (30.0) | 1 (4.0) | 6 (31.6) | 1 (5.6) | |
| Very bad | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Question 8: Ease in ingestion (comparison) | Quite easy to take | 8 (25.0) | 8 (25.8) | 2 (9.5) | 3 (14.3) |
| Slightly easier to take | 6 (18.8) | 8 (25.8) | 3 (14.3) | 5 (23.8) | |
| No difference | 9 (28.1) | 15 (48.4) | 9 (42.9) | 12 (57.1) | |
| Slightly more difficult to take | 8 (25.0) | 0 (0.0) | 7 (33.3) | 1 (4.8) | |
| Quite difficult to take | 1 (3.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Question 9: Convenience | Much more convenient | 7 (21.9) | 3 (9.4) | 2 (9.5) | 6 (28.6) |
| Slightly more convenient | 9 (28.1) | 15 (46.9) | 6 (28.6) | 8 (38.1) | |
| No difference | 14 (43.8) | 14 (43.8) | 13 (61.9) | 7 (33.3) | |
| Slightly less convenient | 2 (6.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Much less convenient | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Question 10: Ease of continuation | Much easier to continue | 6 (18.8) | 2 (6.3) | 1 (4.8) | 4 (19.1) |
| Slightly easier to continue | 6 (18.8) | 13 (40.6) | 6 (28.6) | 3 (14.3) | |
| No difference | 17 (53.1) | 17 (53.1) | 12 (57.1) | 14 (66.7) | |
| Slightly less easy to continue | 3 (9.4) | 0 (0.0) | 2 (9.5) | 0 (0.0) | |
| Much less easy to continue | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Question 11: Reliability | Much more reliable | 2 (6.3) | 7 (21.9) | 6 (28.6) | 6 (28.6) |
| Slightly more reliable | 11 (34.4) | 9 (28.1) | 5 (23.8) | 5 (23.8) | |
| No difference | 19 (59.4) | 16 (50.0) | 10 (47.6) | 10 (47.6) | |
| Slightly less reliable | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Much less reliable | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Question 12: Desire to change | Desire to change | 12 (44.4) | 19 (63.3) | 6 (30.0) | 10 (55.6) |
| No desire to change | 15 (55.6) | 11 (36.7) | 14 (70.0) | 8 (44.4) |
aEdoxaban film-coated tablet only
bcompared with the current medication
cedoxaban OD tablet 30 mg without water
dedoxaban OD tablet 30 mg with water
eedoxaban OD tablet 60 mg without water
fedoxaban OD tablet 60 mg with water
OD orally disintegrating