Table 2.
Demographics by age at enrollment
| Characteristic | Children (age < 18 y) (n = 121) | Adults (age ≥ 18 y) (n = 148) | Total (N = 269) |
|---|---|---|---|
| Age at enrollment,a y | n = 121 | n = 148 | n = 269 |
| Mean (SD) | 5.7 (4.7) | 48.8 (15.4) | 29.4 (24.5) |
| Median (min, max) | 4.3 (−0.01, 17.3) | 51.4 (18.5, 78.9) | 26.0 (−0.01, 78.9) |
| Sex, n (%) | n = 121 | n = 148 | n = 269 |
| Female | 74 (61.2) | 108 (73.0) | 182 (67.7) |
| Race,b n (%) | n = 111 | n = 140 | n = 251 |
| White | 64 (57.7) | 126 (90.0) | 190 (75.7) |
| Asian | 35 (31.5) | 3 (2.1) | 38 (15.1) |
| American Indian or Alaska Native | 0 | 2 (1.4) | 2 (0.8) |
| Native Hawaiian or other Pacific Islander | 0 | 1 (0.7) | 1 (0.4) |
| Other/multiple | 5 (4.5) | 4 (2.9) | 9 (3.6) |
| Not reported | 7 (6.3) | 4 (2.9) | 11 (4.4) |
| Ethnicity,b n (%) | n = 121 | n = 147 | n = 268 |
| Not Hispanic or Latino | 103 (85.1) | 116 (78.9) | 219 (81.7) |
| Hispanic or Latino | 4 (3.3) | 18 (12.2) | 22 (8.2) |
| Not reported | 14 (11.6) | 13 (8.8) | 27 (10.1) |
| Family history of HPP, n (%) | n = 117 | n = 135 | n = 252 |
| Yes | 50 (42.7) | 66 (48.9) | 116 (46.0) |
| No | 61 (52.1) | 54 (40.0) | 115 (45.6) |
| Not reported | 6 (5.1) | 15 (11.1) | 21 (8.3) |
| Treated with asfotase alfa at enrollment, n (%) | n = 121 | n = 148 | n = 269 |
| Yes | 45 (37.2) | 26 (17.6) | 71 (26.4) |
HPP hypophosphatasia, SD standard deviation
aNegative values for age indicate enrollment date occurred during pregnancy
bThe race and ethnicity categories used are those recommended by the US National Institutes of Health