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. 2018 Nov 21;74(3):654–662. doi: 10.1093/jac/dky462

Figure 1.

Figure 1.

Inhibitory effect of baloxavir acid (BXA) in combination with NAIs on CPE in cultured cells infected with influenza A virus. MDCK cells were infected with A/PR/8/34 (H1N1) in the presence of various concentrations of the indicated compounds and cell viability was assessed at 2 days post-infection. The combination effects are shown by isobologram plot (a) and MacSynergy analysis (b). For the isobologram plot, the EC50 of each substance alone and at a fixed concentration of the other were determined. (DA/A + B)/DA and (DB/A + B)/DB were plotted on the x- and y-axes, respectively; DA is the EC50 of substance A alone, DB is the EC50 of substance B alone, DA/A + B is the concentration of substance A giving 50% inhibition in combination with substance B, and DB/A + B is the concentration of substance B giving 50% inhibition in combination with substance A. LAN, laninamivir; OSA, oseltamivir acid; PER, peramivir trihydrate; ZAN, zanamivir hydrate.