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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Biomaterials. 2018 Nov 28;192:475–485. doi: 10.1016/j.biomaterials.2018.11.012

Figure 3. Pharmacokinetics and biodistribution of ZIPPs.

Figure 3.

A. Circulating ZIPPs and ELPs in plasma as a function of time following a single i.v. injection. The data represent mean ± SE (n=5). The plasma concentration was fit to a two-compartment model, which yielded the pharmacokinetic parameters in Table 2. B. Plasma pharmacokinetics upon s.c. administration, shown as mean ± SE (n=3-4). Data from the s.c. administration study was fit to a non-compartmental model to determine the parameters in Table 3. C. Plasma pharmacokinetics upon i.v. administration for a shorter ZIPP, (VPKEG)80. Data represent mean ± SE (n=4).