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. 2018 Oct 26;219(5):819–828. doi: 10.1093/infdis/jiy580

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Figure 4. — Comparing the levels of antibodies to recombinant antigens of PfEMP1 in samples at acute infection. Total immunoglobulin G (IgG) binding to the recombinant antigens of PfEMP1 1E2 (IT4var19) is presented as DBLα2 (A), CIDRα1 (B), DBLβ12 (C), and DBLγ6 (D). Significantly higher antibody levels to uncomplicated malaria (UM) compared to severe malaria (SM) was only observed for DBLα2 (A) and DBLγ6 (D). Antibody levels are expressed as optical density values measured at 405 nm. Assay was performed once; bars represent median and interquartile range of samples tested in duplicate (n = 235 for SM and n = 213 for UM); P values were calculated using an unpaired Mann–Whitney test. Abbreviations: OD, optical density; SM, severe malaria; UM, uncomplicated malaria.