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. 2019 Feb 8;11:21. doi: 10.3389/fnagi.2019.00021

Table 4.

PD-MCI subtypes, domains and risk of PDD.

Multivariate analysis
PDD N = 18 No-PDD N = 121 HR 95%CI p-value
Model 1: MCI subtypes
Normal Cognition   4 (22.2) 80 (66.1) 1
Amnestic MCI single domain /   5 (4.13) / / /
Non-amnestic MCI single domain   2 (11.1)        10 (8.3) 4.77 0.71-31.9 0.1
Amnestic MCI multi-domain   8 (44.4)  19 (15.7) 8.70 2.01-38.0 0.004
Non-amnestic MCI multi-domain   4 (22.2)   7 (5.8) 21.1   3.89-114.7 <0.0001
Model 2: MCI single domain versus MCI multi-domain
Normal Cognition   4 (22.2) 80 (66.1) 1
MCI single domain   2 (11.1) 15 (12.4) 2.51   0.39-15.8 0.3
MCI multiple domain 12 (66.7) 26 (21.4) 11.7   2.91-47.3 0.001
Model 3: Amnestic MCI versus non-amnestic MCI
Normal Cognition   4 (22.2) 80 (66.1) 1
Amnestic MCI   8 (44.4) 24 (19.8) 6.18   1.51-25.2 0.01
Non-amnestic MCI   6 (33.3) 17 (14.0) 8.58   2.11-15.8 0.003
Impaired domain (at baseline)
Memory   8 (44.4) 33 (27.4) 1.88   0.62-5.64 0.3
Executive function 12 (66.7) 28 (23.1) 7.76   2.31-5.64 0.001
Attention   9 (50.0) 31 (25.6) 4.75   1.44-15.6 0.01
Visuo-spatial function   4 (22.2) 19 (15.7) 1.33   0.39-4.56 0.6
Language 1 (5.6) 1 (0.8) 38.2     3.31-441.3 0.004

Cox proportional-hazards multivariate regression models. PD: Parkinson’s Disease; PD-MCI: PD with Mild Cognitive Impairment; PDD: PD with Dementia; HR: Hazard Ratio; HR adjusted by age sex, UPDRS-ME and education. Impaired domain at baseline = at least one impaired test; for each domain the reference group is “not impaired.”