Table 4.
PD-MCI subtypes, domains and risk of PDD.
| Multivariate analysis |
|||||
|---|---|---|---|---|---|
| PDD N = 18 | No-PDD N = 121 | HR | 95%CI | p-value | |
| Model 1: MCI subtypes | |||||
| Normal Cognition | 4 (22.2) | 80 (66.1) | 1 | ||
| Amnestic MCI single domain | / | 5 (4.13) | / | / | / |
| Non-amnestic MCI single domain | 2 (11.1) | 10 (8.3) | 4.77 | 0.71-31.9 | 0.1 |
| Amnestic MCI multi-domain | 8 (44.4) | 19 (15.7) | 8.70 | 2.01-38.0 | 0.004 |
| Non-amnestic MCI multi-domain | 4 (22.2) | 7 (5.8) | 21.1 | 3.89-114.7 | <0.0001 |
| Model 2: MCI single domain versus MCI multi-domain | |||||
| Normal Cognition | 4 (22.2) | 80 (66.1) | 1 | ||
| MCI single domain | 2 (11.1) | 15 (12.4) | 2.51 | 0.39-15.8 | 0.3 |
| MCI multiple domain | 12 (66.7) | 26 (21.4) | 11.7 | 2.91-47.3 | 0.001 |
| Model 3: Amnestic MCI versus non-amnestic MCI | |||||
| Normal Cognition | 4 (22.2) | 80 (66.1) | 1 | ||
| Amnestic MCI | 8 (44.4) | 24 (19.8) | 6.18 | 1.51-25.2 | 0.01 |
| Non-amnestic MCI | 6 (33.3) | 17 (14.0) | 8.58 | 2.11-15.8 | 0.003 |
| Impaired domain (at baseline)∗ | |||||
| Memory | 8 (44.4) | 33 (27.4) | 1.88 | 0.62-5.64 | 0.3 |
| Executive function | 12 (66.7) | 28 (23.1) | 7.76 | 2.31-5.64 | 0.001 |
| Attention | 9 (50.0) | 31 (25.6) | 4.75 | 1.44-15.6 | 0.01 |
| Visuo-spatial function | 4 (22.2) | 19 (15.7) | 1.33 | 0.39-4.56 | 0.6 |
| Language | 1 (5.6) | 1 (0.8) | 38.2 | 3.31-441.3 | 0.004 |
Cox proportional-hazards multivariate regression models. PD: Parkinson’s Disease; PD-MCI: PD with Mild Cognitive Impairment; PDD: PD with Dementia; HR: Hazard Ratio; HR adjusted by age sex, UPDRS-ME and education. ∗Impaired domain at baseline = at least one impaired test; for each domain the reference group is “not impaired.”