Table 1.
Patient characteristics.
| Parameters | All (n = 33) | Low CRP profile (n = 12) | High CRP profile (n = 21) | P | |
|---|---|---|---|---|---|
| General characteristics | Sex (male/female) | 23/10 | 8/4 | 15/6 | 0.78 |
| Age, years | 57 (33–105) | 53.5 (40.0–75.0) | 60.0 (33.0–105.0) | 0.19 | |
| Etiology of cirrhosis (alcohol/viral/other) | 18/8/7 | 8/4/0 | 10/4/7 | 0.08 | |
| MELD | 15.71 (3.66–39.65) | 13.87 (9.79–38.25) | 20.50 (3.66–39.65) | 0.06 | |
| CHILD | 10 (7–15) | 9 (7–13) | 10 (7–15) | 0.03 | |
| ACLF (no/yes) | 9/24 | 5/7 | 4/17 | 0.16 | |
| CLIF-C-ACLF | 57 (39–84) | 44 (39–57) | 60 (47–84) | 0.002 | |
| Esophageal varices (absent/small/large) | 14/8/11 | 6/2/4 | 8/6/7 | 0.38 | |
| Hepatic encephalopathy (absent/grade 1/grade 2/grade 3/grade 4) | 22/4/3/2/2 | 11/1/0/0/0 | 11/3/3/2/2 | 0.20 | |
| Hepatorenal syndrome (no/yes) | 14/19 | 6/6 | 8/13 | 0.51 | |
| Spontaneous bacterial peritonitis (no/yes) | 26/7 | 12/0 | 14/7 | 0.02 | |
| Blood culture (negative/positive/NA) | 12/6/15 | 4/2/6 | 8/4/9 | 1.00 | |
| Ascites culture (negative/positive/NA) | 24/6/3 | 11/1/0 | 13/5/3 | 0.19 | |
| Laboratory blood | Creatinine [mg/dl] | 1.40 (0.57–4.68) | 1.30 (0.57–2.59) | 1.58 (0.86–4.68) | 0.10 |
| Platelets [106/l] | 120 (7–685) | 108 (38–235) | 120 (7–685) | 0.84 | |
| INR | 1.4 (1.0–5.5) | 1.35 (1.00–2.10) | 1.40 (1.00–5.50) | 0.78 | |
| Bilirubin [mg/dl] | 2.08 (0.37–45.21) | 1.92 (0.75–45.21) | 3.20 (0.37–35.41) | 0.81 | |
| GGT [U/l] | 152 (26–1,139) | 139 (33–585) | 181 (26–1,139) | 0.76 | |
| ALT [U/l] | 32 (8–1,050) | 49.5 (17.0–269.0) | 30.0 (8.0–1050.0) | 0.75 | |
| CRP [mg/l] | 48.8 (5.7–205.0) | 13.55 (5.70–22.20) | 60.20 (27.60–205.00) | 0.000 | |
| Granulocytes [106/l] | 100 (10–1,070) | 40 (10–170) | 230 (10–1,070) | 0.001 | |
| Leucocytes [106/l] | 9.81 (3.34–31.18) | 7.01 (3.60–22.20) | 15.09 (3.34–31.18) | 0.004 | |
| Monocytes [103/l] | 1.09 (0.24–12.80) | 0.86 (0.24–1.90) | 1.13 (0.26–12.80) | 0.43 | |
| IL6 [pg/ml] | 33.53 (3.63–684.84) | 10.97 (3.95–236.71) | 83.42 (3.63–684.84) | 0.002 | |
| IL8 [pg/ml] | 68.78 (5.67–752.26) | 43.76 (15.54–752.26) | 77.84 (7.87–1487.36) | 0.46 | |
| Laboratory ascites | Protein [g/l] | 10 (1–44) | 9.5 (4.0–19.0) | 10.0 (1.0–44.0) | 0.65 |
| Granulocytes [106/l] | 48 (2–2,333) | 48 (7–250) | 48 (2–2,333) | 0.97 | |
| Leucocytes [103/l] | 256 (11–3,031) | 467 (52–887) | 218 (11–3,031) | 0.40 | |
| Lymphocytes/Monocytes [103/l] | 127 (5–740) | 300 (39–740) | 127 (5–698) | 0.15 | |
| IL6 [pg/ml] | 642.67 (7.87–1487.36) | 596.15 (109.56–1226.54) | 653.58 (7.87–1487.36) | 0.45 | |
| IL8 [pg/ml] | 83.75 (10.91–988.56) | 44.91 (15.17–277.70) | 95.55 (10.90–988.56) | 0.15 |
Data are medians and (ranges). The results of Mann–Whitney test for metric variables and Chi-square test for nominal variables comparing patients with low CRP profile to those with high CRP profile are shown with P–value (significantly different comparisons are marked in bold).