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. 2019 Feb 8;10:69. doi: 10.3389/fimmu.2019.00069

Table 2.

Patient characteristics for the subpopulation in which 16S rRNA gene amplicon sequencing was performed in blood and ascites.

Parameters Low CRP profile (n = 6) High CRP profile (n = 4) P
General characteristics Sex (male/female) 5/1 2/2 0.26
Age, years 52.5 (40.0–67.0) 56.0 (33–76) 0.76
Etiology of cirrhosis (alcohol/viral/other) 5/1/0 3/0/1 0.34
MELD 10.26 (9.79–38.25) 18.72 (11.21–24.16) 0.17
CHILD 9.0 (8.0–13.0) 9.5 (8.0–10.0) 0.91
ACLF (no/yes) 4/2 1/3 0.20
Esophageal varices (absent/small/large) 3/0/3 2/1/1 0.17
Hepatic encephalopathy (absent/grade 1/grade 2/grade 3/grade 4) 5/1/0/0 3/1/0/0 0.34
Hepatorenal syndrome (no/yes) 4/2 2/2 0.60
Spontaneous bacterial peritonitis (no/yes) 6/0 3/1 0.20
Blood culture (negative/positive/NA) 2/1/3 0/1/3 0.25
Ascites culture (negative/positive/NA) 6/0/0 3/1/0 0.20
Laboratory blood Creatinine [mg/dl] 0.98 (0.57–2.59) 2.27 (1.07–4.68) 0.17
Platelets [106/l] 69.5 (38.0–235.0) 191.5 (123.5–237.5) 0.26
INR 1.35 (1.00–2.10) 1.20 (1.00–1.20) 0.47
Bilirubin [mg/dl] 2.78 (0.75–45.21) 1.54 (0.73–7.97) 0.61
GGT [U/l] 226.0 (152.0–585.0) 149.5 (78.0–1139.0) 0.47
CRP [mg/l] 14.4 (5.7–22.2) 94.6 (27.6–205.0) 0.01
Leucocytes [106/l] 5.33 (3.60–9.07) 7.37 (6.59–17.30) 0.07
Monocytes [103/l] 0.57 (0.24–0.87) 1.10 (0.73–1.17) 0.10
IL6 [pg/ml] 8.32 (3.95–236.71) 81.66 (19.94–97.29) 0.39
IL8 [pg/ml] 41.80 (15.54–752.26) 66.61 (25.08–192.48) 0.61
Laboratory ascites Protein [g/l] 8 (5–17) 21 (10–44) 0.11
Granulocytes [106/l] 18.5 (7–250) 24.0 (10.0–117.0) 0.91
Leucocytes [103/l] 130.5 (52.0–824.0) 163.0 (47.0–480.0) 0.61
Lymphocytes/Monocytes [103/l] 120.0 (39.0–740.0) 139.5 (37.0–363.0) 0.61
IL6 [pg/ml] 757.19 (109.56–1226.54) 529.64 (7.87–816.83) 0.35
IL8 [pg/ml] 29.93 (17.46–277.70) 116.82 (43.12–224.85) 0.17

Data are medians and (ranges). The results of Mann–Whitney test for metric variables and Chi-square test for nominal variables comparing patients with low CRP profile to those with high CRP profile are shown with P-value (significantly different comparisons are marked in bold).