Table 2.
Patient characteristics for the subpopulation in which 16S rRNA gene amplicon sequencing was performed in blood and ascites.
| Parameters | Low CRP profile (n = 6) | High CRP profile (n = 4) | P | |
|---|---|---|---|---|
| General characteristics | Sex (male/female) | 5/1 | 2/2 | 0.26 |
| Age, years | 52.5 (40.0–67.0) | 56.0 (33–76) | 0.76 | |
| Etiology of cirrhosis (alcohol/viral/other) | 5/1/0 | 3/0/1 | 0.34 | |
| MELD | 10.26 (9.79–38.25) | 18.72 (11.21–24.16) | 0.17 | |
| CHILD | 9.0 (8.0–13.0) | 9.5 (8.0–10.0) | 0.91 | |
| ACLF (no/yes) | 4/2 | 1/3 | 0.20 | |
| Esophageal varices (absent/small/large) | 3/0/3 | 2/1/1 | 0.17 | |
| Hepatic encephalopathy (absent/grade 1/grade 2/grade 3/grade 4) | 5/1/0/0 | 3/1/0/0 | 0.34 | |
| Hepatorenal syndrome (no/yes) | 4/2 | 2/2 | 0.60 | |
| Spontaneous bacterial peritonitis (no/yes) | 6/0 | 3/1 | 0.20 | |
| Blood culture (negative/positive/NA) | 2/1/3 | 0/1/3 | 0.25 | |
| Ascites culture (negative/positive/NA) | 6/0/0 | 3/1/0 | 0.20 | |
| Laboratory blood | Creatinine [mg/dl] | 0.98 (0.57–2.59) | 2.27 (1.07–4.68) | 0.17 |
| Platelets [106/l] | 69.5 (38.0–235.0) | 191.5 (123.5–237.5) | 0.26 | |
| INR | 1.35 (1.00–2.10) | 1.20 (1.00–1.20) | 0.47 | |
| Bilirubin [mg/dl] | 2.78 (0.75–45.21) | 1.54 (0.73–7.97) | 0.61 | |
| GGT [U/l] | 226.0 (152.0–585.0) | 149.5 (78.0–1139.0) | 0.47 | |
| CRP [mg/l] | 14.4 (5.7–22.2) | 94.6 (27.6–205.0) | 0.01 | |
| Leucocytes [106/l] | 5.33 (3.60–9.07) | 7.37 (6.59–17.30) | 0.07 | |
| Monocytes [103/l] | 0.57 (0.24–0.87) | 1.10 (0.73–1.17) | 0.10 | |
| IL6 [pg/ml] | 8.32 (3.95–236.71) | 81.66 (19.94–97.29) | 0.39 | |
| IL8 [pg/ml] | 41.80 (15.54–752.26) | 66.61 (25.08–192.48) | 0.61 | |
| Laboratory ascites | Protein [g/l] | 8 (5–17) | 21 (10–44) | 0.11 |
| Granulocytes [106/l] | 18.5 (7–250) | 24.0 (10.0–117.0) | 0.91 | |
| Leucocytes [103/l] | 130.5 (52.0–824.0) | 163.0 (47.0–480.0) | 0.61 | |
| Lymphocytes/Monocytes [103/l] | 120.0 (39.0–740.0) | 139.5 (37.0–363.0) | 0.61 | |
| IL6 [pg/ml] | 757.19 (109.56–1226.54) | 529.64 (7.87–816.83) | 0.35 | |
| IL8 [pg/ml] | 29.93 (17.46–277.70) | 116.82 (43.12–224.85) | 0.17 |
Data are medians and (ranges). The results of Mann–Whitney test for metric variables and Chi-square test for nominal variables comparing patients with low CRP profile to those with high CRP profile are shown with P-value (significantly different comparisons are marked in bold).