. Author manuscript; available in PMC: 2019 Nov 1.

Published in final edited form as: Circ Cardiovasc Qual Outcomes. 2018 Nov;11(11):e004584. doi: 10.1161/CIRCOUTCOMES.118.004584

Table 2.

Effect of fish oil supplementation on risk of peri-operative bleeding in 1516 patients undergoing cardiac surgery in the OPERA trial.

	Fish oil (n=758)	Placebo (n=758)	OR or RR^† (95% CI)	P value
BARC type 4 or 5 bleeding, No (%)	42 (5.51)	50 (6.61)	0.81 (0.53, 1.24)	0.34
TIMI major bleeding, No (%)	31 (4.12)	42 (5.51)	0.71 (0.44, 1.14)	0.16
TIMI minor bleeding, No (%)	54 (7.11)	59 (7.81)	0.89 (0.60, 1.30)	0.55
ISTH surgical bleeding, No (%)	45 (5.92)	54 (7.10)	0.80 (0.53, 1.21)	0.30
24-hr chest tube output, ml, median (IQR)	388 (330)	370 (300)		0.48
Total units of blood transfused, mean (SD)	1.61 (2.62)	1.92 (3.33)	0.83 (0.77, 0.90)	<0.001
median (25^th, 75^th percentile)	1.00 (0, 2.00)	1.00 (0, 3.00)
Total units during surgery, mean (SD)	0.80 (1.51)	1.00 (1.80)	0.84 (0.76, 0.94)	0.002
median (25^th, 75^th percentile)	0 (0, 2.00)	0 (0, 2.00)
Total units after surgery, mean (SD)	0.81 (1.82)	0.92 (2.13)	0.85 (0.76, 0.95)	0.006
median (25^th, 75^th percentile)	0 (0, 1.00)	0 (0, 1.00)

Abbreviations: OR, odds ratio; RR, rate ratio; CI, confidence interval; BARC, Bleeding Academic Research Consortium; IQR, interquartile range; SD, standard deviation;

^†

The first four estimates are odds ratios; the remainder, rate ratios.