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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Front Biol (Beijing). 2018 Aug 20;13(4):277–286. doi: 10.1007/s11515-018-1513-3

Figure 1.

Figure 1

The genotypic and phenotypic properties that define the metastatic tumor cells. The specific features of metastatic tumor cells could be defined on genomic and phenotypic levels. Both germline and somatic alterations including SNVs, CNAs, chromosome rearrangement and epigenetic modulations would lead to changes in the transcriptome of metastatic tumor cells. These genomic changes would not only serve as evolution markers in metastasis, but also manifest functions of cell proliferation, migration, invasion, anti-apoptosis and stemness that would be closely related to the CSC and EMT phenotypes.