Table 3.
Risk factors associated with the mortality of cancer patients with EC-caused BSI
| Characteristics | Survivors (n=253) | Non-survivors (n=71) | P-value | OR (95% CI) | P-valuea |
|---|---|---|---|---|---|
|
| |||||
| Demographics | |||||
| Age (years), median (range) | 63 (19–85) | 61 (34–80) | 0.235 | ||
| Males (n %) | 128 (50.59) | 28 (39.44) | 0.112 | ||
| Comorbidities | |||||
| Hypertension | 92 (36.36) | 20 (28.17) | 0.192 | ||
| Chronic heart disease | 42 (16.60) | 10 (14.08) | 0.558 | ||
| Diabetes mellitus | 32 (12.65) | 17 (23.94) | 0.020 | 1.21 (0.67–2.17) | 0.53 |
| Underlying disease | |||||
| Solid tumor | 240 (94.86) | 65 (91.55) | 0.231 | ||
| Hematological disease | 13 (5.14) | 6 (8.45) | |||
| LOS | 29.05±21.69 | 34.70±23.45 | 0.048 | 1.00 (0.99–1.01) | 0.96 |
| ICU admission | 19 (7.51) | 15 (21.13) | 0.002 | 2.08 (1.13–3.84) | 0.02 |
| Invasive procedure | 122 (48.22) | 38 (53.52) | 0.494 | ||
| Mechanical ventilation | 56 (22.13) | 42 (59.16) | <0.001 | 1.27 (0.44–3.63) | 0.66 |
| Metastasis | 100 (39.53) | 46 (64.79) | <0.001 | 2.71 (1.59–4.63) | 0.001 |
| Chemotherapy | 147 (58.10) | 43 (60.56) | 0.712 | ||
| Surgery | 134 (52.96) | 39 (54.93) | 0.833 | ||
| Previous blood transfusion | 98 (38.74) | 31 (43.66) | 0.520 | ||
| ESBL | 121 (47.83) | 39 (54.93) | 0.310 | ||
| BF | 51 (20.16) | 30 (42.25) | <0.001 | 2.20 (1.33–3.63) | 0.002 |
| Organ failure | 12 (4.74) | 47 (66.20) | <0.001 | 10.33 (5.92–18.03) | <0.001 |
| Sepsis shock | 17 (6.72) | 29 (40.85) | <0.001 | 2.17 (1.24–3.78) | 0.006 |
Note:
a
Multivariate logistic regression analysis.
Abbreviations: BF, biofilm formation; BSI, bloodstream infection; EC, Escherichia coli; ESBL, extended-spectrum β-lactamase; ICU, intensive care unit; LOS, length of hospital stay (days).