Table I.
Baseline characteristics of CLL patients.
| Patients (N = 1143) | Number (%), median [range] |
|---|---|
| Age at diagnosis (years) | 63.0 [23.7–89.5] |
| Age <60 | 464 (41%) |
| Age 60–69 | 372 (33%) |
| Age 70+ | 307 (27%) |
| Sex | |
| Male | 769 (67) |
| Female | 374 (33) |
| Race | |
| Caucasian | 1066 (98) |
| Non-Caucasian | 27 (2) |
| Missing | 50 |
| ALC (× 109/l) | 9.5 [0.4–958] |
| ALC <25 | 940 (83%) |
| ALC 25–50 | 88 (8%) |
| ALC >50 | 101 (9%) |
| Missing | 14 |
| Haemoglobin (g/l) | 141 [49–179] |
| Missing | 11 |
| Platelet count (× 109/l) | 198 [19–675] |
| Missing | 12 |
| Creatinine clearance (ml/min) | 85.4 [9.5–251.1] |
| Missing | 287 |
| Albumin (g/l) | 37 [11–50] |
| Missing | 246 |
| Total bilirubin (μmol/l) | 0.03 [0.005–1.3] |
| Missing | 240 |
| Rai stage | |
| 0 | 629 (55) |
| I–II | 458 (40) |
| III–IV | 55 (5) |
| Missing | 1 |
| B2M | |
| < 35 mg/l | 845 (81) |
| ≥ 35 mg/l | 194 (19) |
| Missing | 104 |
| CD49d | |
| Negative (<45%) | 707 (69) |
| Positive (≥45%) | 317 (31) |
| Missing | 119 |
| CD49d | |
| Negative (<30%) | 658 (64) |
| Positive (≥30%) | 365 (36) |
| Missing | 120 |
| IGHV | |
| Mutated | 559 (56) |
| Unmutated | 436 (44) |
| Missing | 148 |
| High-Risk FISH | |
| No (negative, del13q, +12) | 903 (86) |
| Yes (del11q, del17p) | 148 (14) |
| Missing/Other | 92 |
ALC, absolute lymphocyte count; B2M, beta-2-microglobulin; FISH, fluorescence in situ hybridization; IGHV, Immunoglobulin heavy chain variable region gene.