Table 5. Autism Quotient (AQ) scores in our sample of female carriers of genetic mutations associated with X-linked ichthyosis (XLI) and a normative general population control sample.
| Female carriers for XLI-associated mutations (n = 90) | Normative adult female sample (n = 98, [25]) | Statistical comparison | |
|---|---|---|---|
| Total score | 21.0 (95%CI: 18.0–23.0); 21.6±8.8 | 15.4±5.7 | t[150] = 5.66, p<0.0001 |
| Social skill | 4.0 (95%CI: 2.0–5.0); 4.0±2.9 | 2.3±2.2 | t[164] = 4.51, p<0.0001 |
| Attention switching | 5.0 (95%CI: 4.5–6.0); 5.3±2.4 | 3.6±1.8 | t[166] = 5.67, p<0.0001 |
| Attention to detail | 5.0 (95%CI: 4.0–6.0); 5.3±2.4 | 5.4±2.3 | t[183] = -0.36, p = 0.72 |
| Communication | 3.0 (95%CI: 3.0–4.0); 3.9±2.4 | 2.1±1.8 | t[164] = 5.70, p<0.0001 |
| Imagination | 2.0 (95%CI: 2.0–3.0); 3.1±2.2 | 1.9±1.5 | t[153] = 4.16, p<0.0001 |