Table 9. Pregnancy and childbirth-related medical complications in our sample of female carriers of genetic mutations associated with X-linked ichthyosis (XLI) and our adult female general population sample of mothers; note that one individual could have experienced multiple complications.
| Female carrier mothers for XLI-associated mutations (n = 83) | General UK and USA population sample of mothers (n = 263) | Statistical comparison | ||
|---|---|---|---|---|
| Medical complications during pregnancy or childbirth | Delayed or prolonged labour | 52(63%) | 50(19%) | χ2[1] = 55.7, p<0.0001 |
| Premature labour | 17(20%) | 53(20%) | χ2[1] = 0.01, p = 0.92 | |
| Loss of pregnancy or miscarriage | 17(20%) | 63(24%) | χ2[1] = 0.25, p = 0.62 | |
| Pre-eclampsia or high blood pressure | 14(17%) | 40(15%) | χ2[1] = 0.04, p = 0.84 | |
| Gestational diabetes | 12(14%) | 20(8%) | χ2[1] = 2.76, p = 0.10 | |
| Thyroid problems | 5(6%) | 14(5%) | χ2[1] = 0.0, p = 1.00 | |