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. Author manuscript; available in PMC: 2020 Jan 9.
Published in final edited form as: Cell Host Microbe. 2018 Dec 20;25(1):113–127.e6. doi: 10.1016/j.chom.2018.11.009

Figure 6. Resistant starch suppresses lupus-related mortality and pathogenesis.

Figure 6.

TLR7.1 Tg and C57B1/6 mice treated with IMQ were fed RS. (A) Survival analysis of TLR7.1 Tg mice fed with RS compared to CTRL diet. Experimental cohorts of TLR7.1 Tg and C57B1/6 mice were sacrificed for organ weights, immunologic, and histologic analyses. (B) Weights of spleen and liver. (C) Relative mRNA expression of type I IFN in spleen and ileum. (D) Systemic type I IFN responses in serum measured with a reporter cell line. (E-F) Cells from spleen, MLN, PP, and SI-LP were isolated and analyzed by flow cytometry. (E) Frequency of pDCs in spleen, MLN, PP, and SI-LP. (F) Total spleen and pDCs numbers. (G) Representative H&E staining of kidney tissue. (H) Histopathologic scoring for glomerulonephritis. (I) Quantification of proteinuria. The results are expressed as mean ± SEM (Survival cohorts n=8–28 mice per group, Experimental cohorts n=3–20 mice per group). The results are representative of at least two independent experiments. *P <0.05 was considered statistically significant; **P<0.01; ***P<0.001; ****P<0.0001; ns=not significant; NC=negative control; PC=positive control. See also Figure S6 and Table S6.