Theodoraki 2016.
| Trial name or title | The effect of transversus abdominis plane block on acute and chronic pain after inguinal hernia repair |
| Methods | Double‐blinded (participant, outcome assessor), placebo‐controlled, randomized clinical trial Sequence generation not described Follow‐up for 6 months |
| Participants | Participants: 35 adults in a university setting in Athens, Greece Operation: inguinal hernia repair 2 groups, size: not specified Age (± SD), group 1, 2: not specified Men/women, group 1, 2: not specified Exclusion criteria: inability to consent to the study; BMI > 40 kg/m2; skin infection at the puncture site; contraindication to monoamide LAs, paracetamol, NSAID's (parecoxib); preoperative use of opioids or NSAIDs for chronic pain conditions |
| Interventions |
Group 1 (ropivacaine): during the operation participants all received remifentanil infusion titrated as to maintain heart rate and systolic arterial pressure within 20% of baseline. In the PACU, participants received morphine boluses, until the NRS score was ≤ 3. They also had access to PCA device administering 1 mg doses of morphine as rescue analgesia. TAP block was applied intraoperatively using 20 mL of 0.75% ropivacaine Group 2 (control): same intervention as above except saline was substituted for ropivacaine for TAP block Adjuvants: none Immediate post‐op pain control: meaningful improvement |
| Outcomes | Dichotomous: none Continuous: NRS Secondary: intraoperative dose of remifentanil, mg of IV morphine used in the PACU, and total dose of morphine administered via the PCA device |
| Starting date | January 2014 |
| Contact information | Anne Theodoraki, M.D. Email: ktheodoraki@hotmail.com |
| Notes | ClinicalTrials.gov Identifier: NCT02030223 |
BMI: body mass index; BPI: Brief Pain Inventory; g: gram; GA: general anaesthesia; h: hours; IV: intravenous; mg: milligram; LA: local anaesthetic; N/A: not applicable; NHS: National Health Service; NRS: numerical rating scale; OBAS: overall benefits of analgesia score; PACU: postanaesthesia care unit; PCA: patient controlled analgesia; TAP: transversus abdominis plane; TEA: thoracic epidural anaesthesia; VAS: visual analogue scale; µg: microgram