Table 1.
Common SCN10A Coding Variant Associations with the PR interval
| CHARGE Targeted Sequencing (EA, n=3699) | Exome Sequencing Project (EA, n=607) | Exome Sequencing Project (AA, n=972) | CHARGE Exome Chip Project (EA, n=20666) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP ID | Amino acid substitution | A1/A2 | Freq* (%) | β (SE) [msec] | P value | β (SE) [msec] | P value | Freq† (%) | β (SE) [msec] | P value | Freq† (%) | β (SE) [msec] | P value |
| PR interval | |||||||||||||
| rs57326399 | I962V | T/C | 25.2 | −2.22 (0.94) | 6.7×10−3 | −2.83 (1.54) | 0.07 | 10.2 | 0.01 (1.83) | 0.99 | 25.8 | −1.93 (0.25) | 9.75×10−15 |
| rs73062575 | P1045T | G/T | 2.4 | 5.36 (2.03) | 6.8×10−4 | 12.69 (3.70) | 6.5×10−4 | 0.6 | 10.79 (6.98) | 0.12 | 2.7 | 3.4 (0.68) | 4.87×10−7 |
| rs6795970 | V1073A | A/G | 58.3 | −3.94 (0.67) | 8.9×10−12 | −5.13 (1.43) | 3.6×10−4 | 90.2 | −2.14 (1.89) | 0.26 | 60.2 | −3.31 (0.22) | 2.73×10−49 |
| rs12632942 | L1092P | A/G | 23.6 | −2.12 (0.74) | 5.2×10−4 | −2.75 (1.56) | 0.08 | 13.9 | 2.06 (1.59) | 0.19 | 26.0 | −1.69 (0.25) | 1.02×10−11 |
| rs74717885 | I206M | T/C | 1.3 | −6.74 (3.03) | 0.12 | −1.19 (5.48) | 0.83 | 0.2 | NA | 1.3 | −1.87 (2.86) | 0.51 | |
| rs7630989 | S509P | A/G | 2.7 | −4.75 (2.00) | 0.20 | −2.03 (4.46) | 0.65 | 20.9 | −1.6 (1.31) | 0.22 | 3.1 | −2.23 (1.92) | 0.25 |
| rs77804526 | V1697I | C/T | 1.0 | −5.60 (3.44) | 0.80 | 1.40 (5.95) | 0.82 | 0.2 | NA | 1.3 | −1.51 (3.0) | 0.61 | |
*
Frequency in CHARGE-TSS population,
†
Frequency in ESP African American population
Abbreviations: EA, European American; AA, African American; Freq, coded allele frequency; A1 non-coded allele, A2 coded allele