Table 3.
Association of TG with the incidence of T2DM across tertiles of GRS in the WGHS (fasting sample)
| 1st GRS tertile | 2nd GRS tertile | 3rd GRS tertile | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Model | HR | HR (95% CIs) | HR | HR (95% CIs) | HR | HR (95% CIs) | Pinteraction | ||||
| Triglycerides (mmol/L) | Basic | 1.98 | 1.83 | 2.14 | 1.72 | 1.60 | 1.85 | 1.68 | 1.58 | 1.80 | 0.0007 |
| Full | 1.55 | 1.41 | 1.71 | 1.35 | 1.24 | 1.48 | 1.40 | 1.30 | 1.51 | 0.032 | |
| TRLP (nmol/L) | Basic | 1.01 | 1.01 | 1.01 | 1.01 | 1.00 | 1.01 | 1.01 | 1.01 | 1.01 | 0.161 |
| Full | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.650 | |
| Full + TG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.336 | |
| Very large TRLP | Basic | 1.67 | 1.54 | 1.82 | 1.45 | 1.32 | 1.58 | 1.64 | 1.52 | 1.76 | 0.824 |
| Full | 1.42 | 1.30 | 1.56 | 1.20 | 1.08 | 1.35 | 1.38 | 1.26 | 1.50 | 0.504 | |
| Full + TG | 1.11 | 0.98 | 1.26 | 0.95 | 0.82 | 1.10 | 1.14 | 1.01 | 1.28 | 0.319 | |
| Large TRLP | Basic | 1.21 | 1.18 | 1.24 | 1.15 | 1.13 | 1.18 | 1.14 | 1.12 | 1.17 | 0.0006 |
| Full | 1.11 | 1.08 | 1.15 | 1.07 | 1.04 | 1.09 | 1.07 | 1.04 | 1.10 | 0.025 | |
| Full + TG | 1.02 | 0.97 | 1.06 | 0.99 | 0.94 | 1.03 | 0.97 | 0.93 | 1.01 | 0.013 | |
| Medium TRLP (nmol/L) | Basic | 1.03 | 1.02 | 1.04 | 1.03 | 1.02 | 1.03 | 1.02 | 1.01 | 1.03 | 0.007 |
| Full | 1.01 | 1.00 | 1.02 | 1.01 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 0.039 | |
| Full + TG | 0.98 | 0.97 | 0.99 | 0.98 | 0.98 | 0.99 | 0.97 | 0.97 | 0.98 | 0.012 | |
| Small TRLP (nmol/L) | Basic | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | 0.018 |
| Full | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | 0.317 | |
| Full + TG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.620 | |
| Very small TRLP (nmol/L) | Basic | 1.01 | 1.01 | 1.01 | 1.01 | 1.01 | 1.01 | 1.01 | 1.01 | 1.01 | 0.298 |
| Full | 1.01 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 | 1.01 | 1.01 | 1.01 | 0.253 | |
| Full + TG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 | 0.648 | |
| TRLZ (nm) | Basic | 1.07 | 1.06 | 1.08 | 1.06 | 1.05 | 1.07 | 1.07 | 1.06 | 1.08 | 0.675 |
| Full | 1.05 | 1.04 | 1.06 | 1.03 | 1.02 | 1.04 | 1.04 | 1.03 | 1.05 | 0.429 | |
| Full + TG | 1.03 | 1.01 | 1.04 | 1.01 | 0.99 | 1.02 | 1.02 | 1.01 | 1.04 | 0.171 | |
| TRLTG (mmol/L) | Basic | 2.64 | 2.29 | 3.04 | 1.97 | 1.77 | 2.20 | 2.03 | 1.83 | 2.27 | 0.004 |
| Full | 1.65 | 1.39 | 1.95 | 1.37 | 1.19 | 1.58 | 1.47 | 1.28 | 1.68 | 0.111 | |
| Full + TG | 0.73 | 0.56 | 0.95 | 0.69 | 0.51 | 0.91 | 0.72 | 0.56 | 0.93 | 0.038 | |
| TRLTC (mmol/L) | Basic | 4.60 | 3.38 | 6.27 | 3.10 | 2.37 | 4.06 | 3.46 | 2.63 | 4.55 | 0.078 |
| Full | 1.81 | 1.28 | 2.56 | 1.44 | 1.05 | 1.98 | 1.74 | 1.26 | 2.39 | 0.414 | |
| Full + TG | 0.60 | 0.39 | 0.92 | 0.61 | 0.40 | 0.92 | 0.72 | 0.48 | 1.06 | 0.132 | |
Basic model was adjusted with age, PCs, VE and ASA
Fully adjusted model was adjusted with basic model + BMI, HDL
Full + TG: fully adjusted model + TG