Skip to main content
. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Curr Opin Rheumatol. 2019 Mar;31(2):134–143. doi: 10.1097/BOR.0000000000000582

Figure 1: Point-of-care Raman spectroscopy.

Figure 1:

The point-of-care Raman spectroscopy (POCRS) system consists of 2 parts: a syringe microfiltration kit for isolating and collecting arthritic crystals from synovial fluid (a–c) and a shoebox-sized optoelectromechanical system for acquiring diagnostic signals (d and e). To use the system, synovial fluid is loaded in a glass vial with digestive enzymes (a). After 30 minutes of digestion at 408C, the uric acid–supplemented buffer (b) is used to dilute the digested synovial fluid. Following dilution, the synovial fluid is transferred into a standard syringe (c) and pushed through the disposable microfiltration cartridge for crystal collection. After microfiltration, the cartridge is directly inserted into the optoelectromechanical system (d) for diagnostic signal acquisition (e).