Table 1.
Association Between Markers of Severe Illness or Increased Risk for Bleeding and Platelet Transfusion on Days During the First 7 Days of Life With a Platelet Count <100 000/μL
| Presence of Marker, No. (%) of Patient-days | |||
|---|---|---|---|
| With Platelet Transfusion (n = 212) |
Without Platelet Transfusion (n = 190) |
||
| Conventional mechanical ventilation, high-frequency oscillator, or high-frequency jet ventilation | 192 (90.6) | 96 (50.5) | <.001 |
| Hemodynamic support consisting of dopamine hydrochloride or dobutamine hydrochloride, ≥5 μg/kg/min, or epinephrine at any dose | 68 (32.1) | 18 (9.5) | .001 |
| Administration of indomethacin or ibuprofen for patent ductus arteriosus or heparin sodium for anticoagulation (ie, not for line patency) within the prior 24 h | 17 (8.0) | 14 (7.4) | .90 |
| Coagulopathy indicated by INR >2, fibrinogen level <100 mg/dL, or PTT >1.5 × mean reference value for age12 within the prior 48 h | 21 (9.9) | 9 (4.7) | .14 |
| Surgery or other invasive procedures within the prior 72 h or the subsequent 24 h | 28 (13.2) | 7 (3.7) | .007 |
| Pulmonary, Gl, GU, wound, or other hemorrhage during the prior 48 h (not including IVH) | 42 (19.8) | 6 (3.2) | <.001 |
| Ultrasonographic findings consistent with the diagnosis or extension of IVH by Papile et al13 grading system within the prior 7 d | 97 (45.8) | 39 (20.5) | .005 |
| Any marker | 198 (93.4) | 113 (59.5) | <.001 |
Abbreviations: GI, gastrointestinal tract; GU, genitourinary; INR, international normalized ratio; IVH, intraventricular hemorrhage; PTT, partial thromboplastin time.
SI conversion factor: To convert fibrinogen to micromoles per liter, multiply by 0.0294.
a
P values were calculated using a generalized linear model, taking into account potential correlations between different patient-days for the same patient.