Table 3.
Association Between Prior Platelet Transfusion and Risk for IVH Outcomes During the First 7 Days of Life
| IVH Outcome | Prior Platelet Transfusion as a Risk Factor for IVH | |||||
|---|---|---|---|---|---|---|
| Unadjusted Model | Model for Adjusted Clinical Covariatesa |
Model for Adjusted Clinical Covariates and Nadir PCTb |
||||
| HR(95%CI) | P Value | HR(95%CI) | P Value | HR (95% Cl) | P Value | |
| Any grade IVH (134 of 756 neonates)c | 2.25 (1.30–3.89) | .004 | 1.47 (0.83–2.62) | .19 | 0.92 (0.49–1.73) | .80 |
| Grade III or IV IVH (62 of 772 neonates)d | 4.05 (2.16–7.60) | <.001 | 2.43 (1.24–4.77) | .01 | 1.24(0.59–2.60) | .57 |
Abbreviations: HR, hazard ratio; IVH, intraventricular hemorrhage; PCT, platelet count.
Includes sex, gestational age less than 28 vs at least 28 weeks, 5-minute Apgar score less than 7 vs at least 7, antenatal corticosteroid treatment, and pregnancy-induced hypertension as an indication for delivery. All models are restricted to infants who have no missing data for any of the clinical covariates.
Includes all variables listed in footnote “a,” plus whether the nadir PCT to date is less than 150 000/μL or at least 150 000/μL (to convert to ×109 per liter, multiply by 0.001).
Omits infants with any IVH on the first day of life.
Omits infants with grade III or IV IVH on the first day of life.