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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Sci Transl Med. 2017 Oct 25;9(413):eaao1214. doi: 10.1126/scitranslmed.aao1214

Figure 1.

Figure 1

Mutational profile defines in vivo fates of AML patient-derived cells

1. Somatic mutation profiles were identified in patient cell subpopulations defined by surface phenotype based on developmental hierarchy of human hematopoiesis. 2. In vivo fate of each subpopulation was determined through transplantation into newborn NSG mice. If repopulation by multilineage hematopoiesis occurred, the transplanted subpopulation contained hematopoietic stem cells or pre-leukemic stem cells; if AML engraftment occurred, the transplanted subpopulation contained LICs.