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. Author manuscript; available in PMC: 2019 Mar 18.
Published in final edited form as: Oncogene. 2018 Sep 18;38(7):1121–1135. doi: 10.1038/s41388-018-0498-3

Figure 5. Loss of INPP4B in mouse prostate activates PKC and Akt signaling without changing AR levels.

Figure 5.

(A) Prostates from 2 month old WT or Inpp4b−/− males were stained with INPP4B antibodies and counterstained with hematoxylin. (B-C) RNA was extracted from prostates of WT (N=11) or Inpp4b−/− (N=11) males and analyzed for expression of Inpp4b (B) and Ar (C) by RT-qPCR. (D) Slides from A were stained with AR antibody and counterstained with hematoxylin. (E) Anterior (AP), dorsolateral (DLP), and ventral (VP) prostate lobes from WT or Inpp4b−/− males were analyzed for AR, total PTEN, pPTEN, pPKCζ, pPKCβII, pAkt, total Akt, and tubulin levels by Western blotting.