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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Trends Microbiol. 2018 Oct 15;27(3):254–267. doi: 10.1016/j.tim.2018.09.009

Figure 3. SAMHD1 in cell cycle regulation and PI3K-AKT-IRF3 innate immune signaling.

Figure 3.

SAMHD1 protein expression is high in G0 phase and low in S-phase during the cell cycle. SAMHD1 also impairs apoptosis through PI3K-AKT-p27 axis and thus regulates p27 induced protein expression of TNF-α in NF-κB signaling. SAMHD1 interacts with CDK1/2, which are kinases involved in cell cycle checkpoints. CDK1 and CDK2 are important for regulation of phosphorylation and expression of SAMHD1 during cell cycle. IFNs can reduce SAMHD1 phosphorylation. SAMHD1 controls IFN-I signaling through PI3K-AKT-IRF3 axis. The circled letter P of indicated proteins indicates their phosphorylation. AKT, protein kinase B; CDK1, cyclin dependent kinase 1; CDK2, cyclin dependent kinase 2; PI3K, phosphoinositide 3-kinase.