Figure 8:

Naloxone methiodide increased movement evoked nociception in decitabine-treated mice 12 days post inoculation. A) Administration of naloxone methiodide (100 mg/kg, i.p.) led to a decrease in limb use score in 5 out of 7 cancer-bearing mice treated daily with decitabine. B) In the saline-treated control group 2 out of 9 mice experienced a decrease in limb use score. C) Naloxone methiodide did not induce a significant difference in weight-bearing ratio between the naloxone methiodide-administered group and the saline group. Results were analyzed using an χ2 test.