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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Pain. 2019 Mar;160(3):702–711. doi: 10.1097/j.pain.0000000000001449

Figure 6. CGRP receptor is required for C5a-induced mechanical, but not thermal, hypersensitivity.

Figure 6.

Pre-treatment with the CGRP receptor antagonist BIBN4096 (10 mg/kg IP; n=8) 30 min prior to C5a injection (500 ng) significantly reduced C5a-induced mechanical (A) but not thermal (B) hypersensitivity, compared to vehicle pre-treated animals (n=8). (A) For mechanical sensitivity, there was a significant interaction between the effects of time and treatment: F4,56=4.74, P=0.0023. Significant main effect of time: F4,56=13.38, p<0.0001; Significant main effect of BIBN4096 treatment: F1,14=20.42, p<0.001 (two-way repeated-measures ANOVA). **p<0.01, ***p<0.001, relative to vehicle (Holm-Sidak post hoc test). (B) BIBN4096 pretreatment did not significantly affect C5a-induced thermal hypersensitivity (two-way repeated-measures ANOVA with Holm-Sidak post hoc test). Significant main effect of time: F1,14=206.7, p<0.0001.