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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Pain. 2019 Mar;160(3):702–711. doi: 10.1097/j.pain.0000000000001449

Figure 7. CGRP administration induces mechanical hypersensitivity.

Figure 7.

Intraplantar injection of CGRP (5 µg in 10 µL) in WT (solid black; n=7) and TRPV1 KO mice (solid red; n=11) produced significant mechanical sensitization relative to vehicle-injected WT (dashed black; n=11) and TRPV1 KO (dashed red; n=4). Baseline corresponds to 0 hr time point. There was a significant interaction between the effects of time and treatment: F12,84=2.561, P=0.0061. Significant main effect of time: F4,84=10.2, p<0.001; Significant main effect of treatment/genotype: F3,21=23.76, p<0.001 (two-way repeated-measures ANOVA). *p<0.05, **p<0.01, ***p<0.001, CGRP relative to vehicle injection (Holm-Sidak. post hoc test). Red and black asterisks correspond to TRPV1 KO and WT, respectively. ## p<0.01 is “WT, CGRP” relative to “TRPV1 KO, CGRP” (two-way repeated-measures ANOVA with Holm-Sidak post hoc test, main effects listed above).