Fig. 8.
Model for IAV uncoating and vRNP dynamics. An IAV virion enters the host cell via endocytosis. It then releases vRNP segments separately from late endosomes through fusion and uncoating regulated by host factors in the AN region at 30 to 90 min postinfection. Individual vRNPs finally undergo a three-stage active transport process to arrive at the cell nucleus and display two diffusion patterns within the nucleus.