Table 1.
Enriched pathways shared by REM sleep and corticosterone regulation, or REM sleep and anhedonia
| REMS variables | Overlapping pathways | Apoptosis and survival related pathway |
| Corticosterone regulation | ||
| Bout length | TNFR1 signaling pathway* (PFC) | √ |
| Bout length | Role of IAP-proteins in apoptosis* (PFC) | √ |
| Bout length | Granzyme B signaling* (PFC) | √ |
| Bout length | Regulation of apoptosis by mitochondrial proteins* (PFC) | √ |
| Bout length | Cytoplasmic/mitochondrial transport of proapoptotic proteins Bid, Bmf, and Bim* (PFC) | √ |
| Bout length | Apoptotic TNF-family pathways* (PFC) | √ |
| Bout length | FAS signaling cascades* (PFC) | √ |
| Bout length | Endothelial differentiation during embryonic development† (HYP) | |
| Bout length | Role of Apo-2L(TNFSF10) in Prostate Cancer cell apoptosis‡ (PFC) | √ |
| Bout length | Resistance of melanoma cells to Apo-2L(TNFSF10)-induced apoptosis‡ (PFC) | √ |
| Bout length | Inhibition of apoptosis in gastric cancer‡ (PFC) | √ |
| Bout length | Neutrophil resistance to apoptosis in chronic obstructive pulmonary disease and proresolving impact of lipid mediators‡ (PFC) | √ |
| Bout length | Apo-2L(TNFSF10)-induced apoptosis in melanoma‡ (PFC) | √ |
| Bout length | Apoptotic pathways and resistance to apoptosis in lung cancer cells‡ (PFC) | √ |
| Duration | Endothelial differentiation during embryonic development† (HIP) | |
| Theta power | Role of IAP-proteins in apoptosis* (HIP) | √ |
| Theta power | TNFR-1 signaling pathway* (HIP) | √ |
| Theta power | IL-5 signaling via JAK/STAT§ (HIP) | |
| Theta power | Role of Apo-2L(TNFSF10) in prostate cancer cell apoptosis‡ (HIP) | √ |
| Theta power | Inhibition of apoptosis in gastric cancer‡ (HIP) | √ |
| Theta power | Apoptotic pathways and resistance to apoptosis in lung cancer cells‡ (HIP) | √ |
| Anhedonia | ||
| Bout count | Metabolism in pancreatic cancer cells‡ (BLO) | |
| Bout length | Cytoplasmic/mitochondrial transport of proapoptotic proteins Bid, Bmf, and Bim* (PFC) | √ |
| Bout length | Glucocorticoids-mediated inhibition of proconstrictory and proinflammatory signaling in airway smooth muscle cells‡ (HIP) | |
| Bout length | Memory CD8+ T cells in allergic contact dermatitis‡ (HYP) | |
| Duration | EGF-induced proliferation of Type C cells in secondary proliferative zone of adult brain† (HIP) | |
| Theta power | Memory CD8+ T cells in allergic contact dermatitis‡ (HIP) | |
| Theta power | NRF2 regulation of oxidative stress response‡ (HIP) | |
Tissue in which enriched pathways associated with predictors of REMS variables is indicated in parenthesis (i.e., BLO, blood; HIP, hippocampus; HYP, hypothalamus; PFC, prefrontal cortex). The column “Apoptosis and survival related pathway” indicates whether a pathway was related to apoptosis and survival as some pathways listed under a generic theme in MetaCore are also implicated in apoptotic and antiapoptotic pathways. For each pathway, the functional theme to which it belongs to is listed according to the specified footnote.
*
Apoptosis and survival.
†
Stem cells.
‡
Generic (according to MetaCore).
§
Immune response.