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. 2019 Jan 28;116(7):2701–2706. doi: 10.1073/pnas.1817885116

Fig. 3.

Fig. 3.

The glutathione cycle supports excitatory transmission, but to a smaller degree than glutamine-derived glutamate. (A) Scheme of glutamate-glutamine cycling and blockade of system A glutamine transporters by MeAIB. Details appear in SI Appendix, Fig. S4. (B) Representative traces of mEPSC recordings in primary cortical neurons treated with 25 μM acivicin (24 h) and/or 25 mM MeAIB (2 h). (C and D) Distribution of mEPSC frequency and amplitude in cortical neurons treated with acivicin and/or MeAIB. (E and F) Cumulative probability plots of mEPSC frequency and amplitude. MeAIB decreased mEPSC frequency to a greater degree than acivicin, with both treatments having additive effects for presynaptic drive frequency. (‡P < 0.0001 by Steel–Dwass all pairs test.)