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. 2019 Feb 5;9(2):e027004. doi: 10.1136/bmjopen-2018-027004

Table 2.

BMI and obesity risk of associated SNPs for Hortega, Pizarra and Segovia populations

Genotype HORTEGA PIZARRA SEGOVIA
N BMI (kg/m2) Obesity OR (95% CI) N BMI (kg/m2) Obesity OR (95% CI) N BMI (kg/m2) Obesity OR (95% CI)
SDHC AA 1250 26.46±0.12 1 772 28.70±0.19 1 943 27.71±0.10 1
rs4600063 AG-GG 183 26.16±0.30 0.82 (0.55 to 1.22) 96 27.86±0.04 0.47 (0.28 to 0.78) 132 27.21±0.30 0.88 (0.57 to 1.36)
HWE: 1 P value 0.9 0.33 0.071 0.0025 0.22 0.57
NDUFS1 TT 1308 26.41±0.12 1 799 28.49±0.10 1 1028 27.56±0.10 1
rs3770989 CT-CC 114 26.62±0.44 1.13 (0.72 to 1.77) 77 29.85±0.60 1.5 (0.91 to 2.48) 65 27.92±0.60 1.28 (0.73 to 2.23)
HWE: 1 P value 0.34 0.6 0.016 0.12 0.48 0.39
NDUFS2 AA 1045 26.37±0.13 1 640 28.61±0.21 1 830 27.55±0.15 1
rs1136224 AG-GG 369 26.59±0.23 1.43 (1.09 to 1.89) 223 28.59±0.34 1.10 (0.79 to 1.54) 241 27.77±0.26 1.07 (0.76 to 1.48)
HWE: 0.36 P value 0.25 0.011 0.71 0.58 0.42 0.71
NDUFS5 CC-CG 1309 26.47±0.12 1 832 28.63±0.10 1 947 27.6±0.14 1
rs11205591 GG 115 25.78±0.31 0.67 (0.41 to 1.10) 38 27.66±0.70 0.86 (0.41 to 1.81) 89 27.21±0.40 0.89 (0.53 to 1.5)
HWE: 0.76 P value 0.049 0.11 0.38 0.69 0.25 0.66
SDHD AA 691 26.16±0.16 1 401 28.18±0.26 1 571 27.37±0.17 1
rs10891319 AG-GG 726 26.64±0.16 1.16 (0.90 to 1.49) 478 29.00±0.24 1.22 (0.91 to 1.64) 492 27.83±0.19 1.27 (0.96 to 1.68)
HWE: 0.22 P value 0.08 0.25 0.084 0.18 0.077 0.095

BMI: mean±SD.

Bold: significant.

BMI, body mass index; HWE, Hardy-Weinberg equilibrium; N, number of individuals; SNP, single nucleotide polymorphism.