Fig. 1.

The pipeline of radiomics analysis. The conventional PET/CT analysis approach is composed of imaging (acquisition and reconstruction), preprocessing (tumor segmentation), quantification (PET feature extraction: SUV, MTV and TLG) and statistical analysis (a). The pipeline of radiomics analysis is composed of imaging (acquisition and reconstruction), preprocessing (segmentation and quantization), quantification (histogram or texture matrix design and feature extraction), and analysis (statistics and/or machine learning) (b)