Fig. 1.

Best examples of nuclear medicine procedures used as in vivo companion diagnostics. Among the non-communicable diseases, brain perfusion SPECT helped choose stent insertion or bypass operation for carotid/cerebral artery stenosis/obstruction and myocardial SPECT predicted major adverse cardiac events (cardiac death and acute myocardial infarction) and helped choose needs of stenting/bypass operation for coronary artery diseases. Anatomical imaging with angiography was used to define the diseases and functional imaging with SPECT was used to define the functional significance