TABLE 1.
Co-dominant genotype model age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for diabetes-related SNPs and breast cancer (BC) risk in the LIBCSP (n = 1838)
| Gene | rs ID location | Genotype | 817 BC/1021 no BC | OR (95% CI) | Pa |
|---|---|---|---|---|---|
| SLC30A8 | rs4876369 | AA | 588/802 | 1.00 | |
| Intron | AG | 206/198 | 1.41 (1.12–1.76) | ||
| GG | 16/16 | 1.37 (0.68–2.77) | 0.0034 | ||
| HHEX-EXOC6 | rs11187146 | GG | 582/777 | 1.00 | |
| Intergene | GC | 210/229 | 1.24 (1.00–1.54) | ||
| CC | 21/14 | 2.06 (1.03–4.10) | 0.0086 | ||
| CDKN2A-CDKN2B | rs1333049 | CC | 209/319 | 1.00 | |
| Intergene | CG | 404/483 | 1.28 (1.03–1.59) | ||
| GG | 201/216 | 1.40 (1.08–1.82) | 0.0094 | ||
| MTNR1B | rs10830963 | CC | 458/507 | 1.00 | |
| Intron | CG | 301/426 | 0.78 (0.64–0.95) | ||
| GG | 52/81 | 0.75 (0.52–1.09) | 0.0125 | ||
| TCF7L2 | rs12573128 | AA | 537/725 | 1.00 | |
| Intron | AG | 236/263 | 1.19 (0.97–1.47) | ||
| GG | 35/28 | 1.74 (1.04–2.91) | 0.0129 | ||
| MTNR1B | rs4753426 | CC | 173/249 | 1.00 | |
| Upstream 2KB | CT | 407/528 | 1.09 (0.86–1.38) | ||
| TT | 231/239 | 1.37 (1.05–1.79) | 0.0184 | ||
| IGF2BP2 | rs6794209 | CC | 576/683 | 1.00 | |
| Intron | CT | 221/290 | 0.91 (0.74–1.12) | ||
| TT | 17/43 | 0.44 (0.25–0.79) | 0.0201 | ||
| CDKAL1 | rs201312 | AA | 509/681 | 1.00 | |
| Intron | AG | 262/303 | 1.17 (0.96–1.43) | ||
| GG | 39/32 | 1.60 (0.98–2.59) | 0.0263 | ||
| TCF7L2 | rs290494 | TT | 601/714 | 1.00 | |
| Intron | TG | 192/269 | 0.86 (0.69–1.07) | ||
| GG | 18/34 | 0.60 (0.33–1.07) | 0.0412 | ||
| IRS2 | rs2241745 | AA | 635/755 | 1.00 | |
| Intron | AG | 168/246 | 0.81 (0.64–1.01) | ||
| GG | 9/14 | 0.72 (0.31–1.67) | 0.0458 | ||
| SAT2, SHBG | rs13894 | CC | 700/912 | 1.00 | |
| Intron | CT | 111/105 | 1.36 (1.02–1.81) | ||
| TT | <5/<5 | – | 0.0492 | ||
| HNF1A | rs7310409 | GG | 258/349 | 1.00 | |
| Intron | GA | 378/489 | 1.05 (0.85–1.30) | ||
| AA | 175/177 | 1.33 (1.02–1.73) | 0.0496 | ||
| Sum of “at-risk” allelesb | 0–9 | 172/312 | 1.00 | ||
| 10–11 | 258/375 | 1.22 (0.96–1.56) | |||
| 12–24 | 361/314 | 2.09 (1.64–2.66) | <0.0001 |
Long Island Breast Cancer Study Project (LIBCSP) women without breast cancer were age-matched to women diagnosed with breast cancer between August 1, 1996 and July 31, 1997.
a
Additive genotype model P values.
b
The “at-risk” allele was defined as follows: rs4876369: G allele; rs11187146: C allele; rs1333049: G allele; rs10830963: C allele; rs12573128: G allele; rs4753426: T allele; rs6794209: C allele; rs201312: G allele; rs290494: T allele; rs2241745: A allele; rs13894: A allele; rs7310409: A allele.