TABLE 2.

Additive genotype model age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for diabetes-related SNP genotypes and breast cancer risk, overall and stratified by diabetes status in the LIBCSP (n = 1,833).

Gene	rs ID	Alleles	Overall	Diabetes status		PInteractiona
				No (n = 1706)	Yes (n = 127)
			OR (95% CI)	OR (95% CI)	OR (95% CI)
SLC30A8	rs4876369	A/G	1.34 (1.10–1.63)	1.25 (1.02–1.53)	4.30 (1.66–11.17)	0.0150
HHEX-EXOC6	rs11187146	G/C	1.29 (1.07–1.56)	1.36 (1.12–1.66)	0.72 (0.35–1.46)	0.0925
CDKN2A-CDKN2B	rs1333049	C/G	1.19 (1.04–1.35)	1.17 (1.03–1.34)	1.24 (0.75–2.03)	0.7644
MTNR1B	rs10830963	C/G	0.83 (0.71–0.96)	0.80 (0.69–0.94)	1.35 (0.76–2.41)	0.1008
TCF7L2	rs12573128	A/G	1.24 (1.05–1.47)	1.23 (1.03–1.47)	1.28 (0.66–2.48)	0.9562
MTNR1B	rs4753426	C/T	1.17 (1.03–1.34)	1.21 (1.05–1.39)	0.79 (0.48–1.31)	0.1194
IGF2BP2	rs6794209	C/T	0.81 (0.68–0.97)	0.80 (0.66–0.95)	1.00 (0.53–1.89)	0.3237
CDKAL1	rs201312	A/G	1.21 (1.02–1.42)	1.20 (1.01–1.42)	1.19 (0.61–2.30)	0.9777
TCF7L2	rs290494	T/G	0.83 (0.69–0.99)	0.82 (0.68–0.99)	0.88 (0.46–1.70)	0.7418
IRS2	rs2241745	A/G	0.81 (0.66–1.00)	0.76 (0.61–0.94)	1.76 (0.86–3.58)	0.0283
SAT2, SHBG	rs13894	C/T	1.32 (1.00–1.75)	1.32 (0.99–1.76)	1.23 (0.40–3.81)	0.9506
HNF1A	rs7310409	G/A	1.14 (1.00–1.30)	1.14 (0.99–1.31)	1.17 (0.73–1.85)	0.9377
Sum of “at-risk” allelesb			1.19 (1.13–1.24)	1.19 (1.14–1.25)	1.06 (0.88–1.28)	0.2253

Long Island Breast Cancer Study Project (LIBCSP) women without breast cancer were age-matched to women diagnosed with breast cancer between August 1, 1996 and July 31, 1997.

^aMultiplicative interaction P values.

^bThe “at-risk” allele was defined as follows: rs4876369: G allele; rs11187146: C allele; rs1333049: G allele; rs10830963: C allele; rs12573128: G allele; rs4753426: T allele; rs6794209: C allele; rs201312: G allele; rs290494: T allele; rs2241745: A allele; rs13894: A allele; rs7310409: A allele.