TABLE 4.
Additive genotype model age-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for diabetes-related SNP genotypes and mortality following breast cancer, overall and stratified by diabetes status in the LIBCSP (n = 817)
| Gene | rs ID | Alleles | Overall |
All-Cause Mortality |
PInteractiona | |
|---|---|---|---|---|---|---|
| Diabetes Status | ||||||
| No (n = 758) |
Yes (n = 56) |
|||||
| HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| CDKAL1 | rs981042 | C/A | 1.49 (1.14–1.94) | 1.46 (1.08–1.96) | 1.33 (0.75–2.35) | 0.9699 |
| HHEX-EXOC6 | rs1111875 | G/A | 0.84 (0.72–0.99) | 0.85 (0.72–1.01) | 0.90 (0.56–1.44) | 0.7751 |
| INSR | rs919275 | A/G | 0.86 (0.75–1.00) | 0.89 (0.76–1.04) | 0.61 (0.39–0.97) | 0.1618 |
| Sum of “at-risk” allelesb | 1.21 (1.09–1.34) | 1.17 (1.05–1.31) | 1.33 (1.01–1.76) | 0.3962 | ||
| Breast cancer-specific mortality | ||||||
| Diabetes Status | ||||||
| Overall | No (n = 758) | Yes (n = 56) | ||||
| Alleles | HR (95% CI) | HR (95% CI) | HR (95% CI) | PInteractiona | ||
| CDKN2A, CDKN2B | rs3218020 | C/T | 0.74 (0.58–0.96) | 0.76 (0.58–0.99) | 0.58 (0.25–1.39) | 0.4963 |
| CDKAL1 | rs981042 | C/A | 1.61 (1.06–2.44) | 1.58 (1.00–2.48) | 1.61 (0.60–4.28) | 0.8581 |
| TCF2, HNF1B | rs3094508 | A/G | 0.77 (0.60–0.98) | 0.76 (0.59–0.99) | 0.90 (0.41–1.96) | 0.6659 |
| Sum of “at-risk” allelesc | 1.49 (1.21–1.85) | 1.37 (1.15–1.64) | 1.42 (0.82–2.47) | 0.8127 | ||
Long Island Breast Cancer Study Project (LIBCSP) women diagnosed with breast cancer between August 1, 1996 and July 31, 1997 and followed-up for vital status through December 31, 2014
a
Multiplicative interaction P values.
b
The “at-risk” allele was defined as follows: rs981042: A allele; rs1111875: G allele; rs919275: A allele.
c
The “at-risk” allele was defined as follows: rs3218020: C allele; rs981042: A allele; rs3094508: A allele.