Fig. 6. MPC1 suppresses LAC cells xengraft growth in vivo.

a Nude mice were injected subcutaneously in the right flanks with Ctrl or MPC1-overexpression A549 cells. After 28 days, xenografts were harvested and photographed. b, c Quantitative analysis of the volume (b) and weight (c) of the xenograft tumors. d IHC staining showing the expression of MPC1, P-STAT3(Y705), SOX2, and MMP2 in the xenograft tumors derived from OEMPC1 and Ctrl cells, Scale bar = 25 µm. e Schematic diagram of the regulatory mechanism of MPC1 mediates STAT3 dephosphorylation and inhibits the stemness and invasion of LAC cells. Data are expressed as the mean ± SD,*P<0.05, **P<0.01, ***P<0.001