Fig. 2. Reduced PLOD3 suppresses radioresistance in R-H460 cell xenograft tumor model.
a Tumor volume was calculated at the indicated times using the formula: volume = (length × width2 × 3.14)/6; (n = 8). *P < 0.05; ***P < 0.001. b Tumors were excised and weighed at the end of the experiment (14 days). Representative images of tumors and tumor slides subjected to immunohistochemistry using an anti-PLOD3 antibody. c Effects of siRNA and radiation on tumor weights. Data shown are the means of each group. *P < 0.05; ***P < 0.001. d Body, liver, and lung tissues of mice were excised and weighed at the end of the experiment. All data are shown as the mean ± SD. e Five-year survival rate curves were obtained using Kaplan–Meier Plotter (www.kmplot.com) and display the survival probability based on data of 68 lung cancer patients treated with radiotherapy