Table 2.
Plasma methylphenidate (MP) concentration (ng/ml) after intravenous MP injection in the CUD and HC in the unexpected (PL/MP) and expected (MP/MP) conditions
| CUD (n = 23) | HC (n = 21) | p Value | |
|---|---|---|---|
| PL/MP | |||
| 15 min | 181.0 (56.7) | 161.0 (60.1) | ns |
| 30 min | 117.6 (24.1) | 136.4 (49.2) | ns |
| 45 min | 92.3 (19.9) | 106.6 (21.9) | 0.03 |
| 60 min | 79.1 (18.7) | 93.4 (20.0) | 0.02 |
| Mean | 117.6 (25.8) | 123.3 (30.0) | 0.4 |
| MP/MP | |||
| 15 min | 182.0 (61.2) | 150.1 (53.9) | ns |
| 30 min | 114.8 (34.0) | 133.2 (41.0) | ns |
| 45 min | 91.9 (22.7) | 105.6 (19.7) | 0.04 |
| 60 min | 77.8 (16.7) | 89.1 (17.4) | 0.04 |
| Mean | 116.9 (30.2) | 119.5 (27.0) | ns |
CUD cocaine use disorder, HC healthy controls, PL placebo, ns not significant