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. 2019 Jan 15;10(2):34. doi: 10.1038/s41419-018-1169-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Flow cytometry analysis showed that silencing sirt3 increased TEC apoptosis and necrosis in the presence of CaOx. b ROS activity was significantly upregulated by Sirt3 siRNA transfection. c Western blot showed the expression of Sirt3, cleaved caspase-3 and Bcl-2 with Sirt3 or control siRNA transfection. Sirt3 siRNA transfection effectively inhibited Sirt3 protein expression. In the Sirt3 siRNA group, cleaved caspase-3 expression was significantly increased, and Bcl-2 expression was decreased. Data are shown as the means ± S.D.; n = 3 per group