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. 2019 Jan 15;10(2):34. doi: 10.1038/s41419-018-1169-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Flow cytometry showed that overexpression of sirt3 blocked CaOx-induced apoptosis and necrosis of TEC. b Overexpression of sirt3 significantly reduced ROS levels under CaOx stimulation. c Sirt3 protein expression was rescued in the sirt3-overexpressing group under CaOx stimulation. The cleaved caspase-3 and Bax levels were significantly decreased, and the Bcl-2 level was increased in the sirt3-overexpressing group compared to the non-transfected control group. d The von Kossa staining results revealed that resveratrol reduced calcium deposits in the medulla of the murine nephrolithiasis model. Scale bar: 100 μm (left); 50 μm (right). e Sirt3 expression in both the renal cortex and medulla was increased by resveratrol treatment. Data are shown as the means ± S.D.; n = 6 mice per group. Scale bar: 100 μm (left); 50 μm (right)