Table 3.
Top 15 most significantly enriched KEGG pathways of DEGs in the turquoise module
| KEGGID | Term | Count | FDR | Symbols |
|---|---|---|---|---|
| 03050 | Proteasome | 27 | 2.21E-31 | Psmb9,Psma6,Psmb1,Psma3,Psme2,Psmc2,Psmb2,Psmc6,Psmd11,Psmd6,Psma1,Psmc3,Psma4,Psme1,Psmc1,Psmc5,Psmd2,Psmb3,Psmb4,Psmb10,Psmd13,Psmd1,Psma5,Psma7,Psmd4,Psmc4,Psmd7 |
| 04141 | Protein processing in endoplasmic reticulum | 28 | 3.00E-15 | Bcap31,Dnajb2,Sar1a,Sel1l,Hsp90aa1,Prkcsh,Pdia3,Rad23b,Dnajb1,Hsp90b1,Erp29,Sec61a1,Skp1,Pdia4,Stt3a,Calr,Man1a1,Nsfl1c,Nploc4,Ganab,Dnajc10,P4hb,Ckap4,Lman2,Hsp90ab1,Hsph1,Uggt1,Vcp |
| 04142 | Lysosome | 24 | 6.97E-15 | Man2b1,Naga,Ctsc,Gm2a,Lipa,Lgmn,Ctsd,Abcb9,Fuca1,Glb1,Lamp2,Ctsa,Igf2r,Ap3d1,Atp6v1h,Asah1,Psap,Gns,Ctsb,Tpp1,Ppt1,Napsa,Npc2,Ctsh |
| 00010 | Glycolysis/Gluconeogenesis | 18 | 2.84E-14 | Ldha,Pgm1,Dld,Aldh9a1,Eno3,Aldoc,Akr1a1,Aldh7a1,Tpi1,Aldoa,Aldh1a1,Pck2,Gapdh,Dlat,Pfkp,Pfkm,Pgk1,Pfkl |
| 00020 | Citrate cycle (TCA cycle) | 14 | 8.01E-14 | Idh1,Idh3g,Acly,Dld,Dlst,Suclg1,Aco2,Ogdh,Pck2,Idh2,Sdhb,Mdh2,Aco1,Dlat |
| 04145 | Phagosome | 23 | 3.91E-11 | Rac1,RT1-Bb,Tubb5,RT1-Da,Atp6v1a,Sec61a1,Atp6v1c1,Lamp2,Calr,RT1-DMa,Atp6v1e1,Mpo,Tap1,Atp6v1h,Itga2,RT1-Db1,Tubb2a,Atp6v1b2,Itga5,Cd14,Eea1,Dync1li1,Sftpa1 |
| 00970 | Aminoacyl-tRNA biosynthesis | 13 | 8.60E-11 | Vars,Dars,Yars,Wars,Sars,Farsa,Gars,Nars,Tars,Farsb,Hars,Kars,Aars |
| 00620 | Pyruvate metabolism | 11 | 4.75E-09 | Acaca,Ldha,Dld,Aldh9a1,Aldh7a1,Aldh1a1,Pck2,Akr1b1,Mdh2,Glo1,Dlat |
| 00480 | Glutathione metabolism | 12 | 1.33E-08 | Idh1,Lap3,Txndc12,Gsr,Gss,Mgst1,Gpx7,Gsta4,Gstm1,Idh2,Gstm2,Gstp1 |
| 04612 | Antigen processing and presentation | 14 | 3.14E-08 | Hsp90aa1,RT1-Bb,Psme2,RT1-Da,Pdia3,Lgmn,Calr,RT1-DMa,Tap1,Hspa4,RT1-Db1,Psme1,Ctsb,Hsp90ab1 |
| 05100 | Bacterial invasion of epithelial cells | 13 | 8.79E-08 | Rac1,Arpc1b,Vcl,Arpc5l,Arpc2,Fn1,Elmo1,Dnm2,Arpc3,Itga5,Cav2,Arpc5,Crk |
| 00280 | Valine, leucine and isoleucine degradation | 11 | 1.10E-07 | Dld,Pcca,Aldh9a1,Aldh7a1,Acads,Hmgcl,Bcat2,Aldh1a1,Acadsb,Hadh,Acaa2 |
| 00030 | Pentose phosphate pathway | 9 | 1.26E-07 | Pgm1,Aldoc,Tkt,Taldo1,Aldoa,Pfkp,Pgls,Pfkm,Pfkl |
| 04666 | Fc gamma R-mediated phagocytosis | 13 | 8.76E-07 | Rac1,Arpc1b,Marcks,Arpc5l,Arf6,Dstn,Arpc2,Cfl1,Dnm2,Prkcd,Arpc3,Arpc5,Crk |
| 00052 | Galactose metabolism | 7 | 7.01E-06 | Pgm1,Glb1,Ugp2,Akr1b1,Pfkp,Pfkm,Pfkl |