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. 2019 Feb 15;19:155. doi: 10.1186/s12885-019-5327-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Multivariable Cox hazard regression for LGR5FL (a), LGR5Δ5 (b), LGR5Δ8 (c) and LGR5all (d) mRNA expression level and overall survival in OSCC patients. Relative expression level of LGR5FL, LGR5Δ5, LGR5Δ8 or LGR5all mRNA in 78 OSCC tumor samples was correlated with overall survival. Regarding confounding factors, the Cox model was adjusted to patients’ gender, tumor stage, tumor grading and the occurrence of regional lymph node metastases. The high and low cut-off values for: a. LGR5FL were > 134.3 and ≤ 134.3 LGR5FL mRNA level (HR = 1.5, p = 0.2; CI: 0.8–2.7). b. LGR5Δ5 were > 2.9 and ≤ 2.9 LGR5Δ5 mRNA level (HR = 2.0, p = 0.02; CI: 1.1–3.7). c. LGR5Δ8 were > 14.9 and ≤ 14.9 LGR5Δ8 mRNA level (HR = 1.1, p = 0.66; CI: 0.6–2.1). d. LGR5all were > 8449.3 and ≤ 8449.3 LGR5all mRNA level (HR = 1.7, p = 0.09; CI: 0.9–3.0)